Bovine Respiratory Disease Case Definition

Clinical signs and diagnostic test results were both used to classify calves as BRD cases or controls. Histophilus somni, Pasteurella multocida, Bibersteinia trehalosi and Mannheimia haemolytica were considered as aerobic pathogens when categorizing cases and controls (Griffin et al., 2010 (link)). Calves that met any of the following three criteria were classified as cases: (1) positive for BRSV, BHV-1, or BVDV on PCR; (2) any aerobic pathogen detected on culture and WI Score ≥5; or (3) any Mycoplasma spp. detected on culture and WI Score ≥5. All other calves were classified as controls. Figure 1 depicts the algorithm for the classification of BRD cases and controls. Bovine coronavirus was not included as a criterion for case definition because current PCR assays could not differentiate between enteric and respiratory BCoV subtypes (Saif, 2010 (link)).

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Love W.J., Lehenbauer T.W., Kass P.H., Van Eenennaam A.L, & Aly S.S. (2014). Development of a novel clinical scoring system for on-farm diagnosis of bovine respiratory disease in pre-weaned dairy calves. PeerJ, 2, e238.

Publication 2014

Aerobic Assays Bibersteinia trehalosi Bovine coronavirus Calves Diagnostic test Histophilus somni Mannheimia haemolytica Mycoplasma Pasteurella multocida Pathogen Respiratory

Corresponding Organization :

Other organizations : University of California, Davis

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Variable analysis

independent variables

Presence or absence of BRSV, BHV-1, or BVDV (detected by PCR)
Presence or absence of any aerobic pathogen (Histophilus somni, Pasteurella multocida, Bibersteinia trehalosi, Mannheimia haemolytica) detected on culture
Presence or absence of any Mycoplasma spp. detected on culture
Weighted Integration (WI) Score (≥5 or <5)

dependent variables

Classification of calves as BRD cases or controls

control variables

Not explicitly mentioned

controls

Positive control: Calves positive for BRSV, BHV-1, or BVDV on PCR
Negative control: Calves that did not meet any of the three criteria for BRD cases (classified as controls)

Annotations

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