C11-PIB was synthesized and administered at Massachusetts General Hospital (MGH, Siemens ECAT EXACT HR1 scanner)[36 (link)]. Distribution volume ratio (DVR) images were created with Logan plotting (40–60 min, cerebellar reference). A global cortical aggregate including frontal, lateral, and retrosplenial regions was calculated for each participant, which was subsequently used to dichotomize participants into amyloid negative (Aβ-) and amyloid positive (Aβ+) groups using a cutoff of 1.185 using a Gaussian mixture model[37 (link)]. All statistical models used continuous Aβ, but Aβ was dichotomized for illustrative purposes in the figures.
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PET Imaging of Amyloid Deposition
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Corresponding Organization : Brigham and Women's Hospital
Other organizations : Florey Institute of Neuroscience and Mental Health, University of Melbourne, Stanford University
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Variable analysis
independent variables
- Administration of C11-PIB
- Distribution volume ratio (DVR) images
- Global cortical aggregate including frontal, lateral, and retrosplenial regions
- Amyloid negativity (Aβ-) and amyloid positivity (Aβ+) groups
- Scanning location (Massachusetts General Hospital, Siemens ECAT EXACT HR1 scanner)
- Logan plotting (40–60 min, cerebellar reference)
- Gaussian mixture model with a cutoff of 1.185 for dichotomizing participants into Aβ- and Aβ+ groups
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