Synthesis of 4-(2-(2-mercapto-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamide

Stirring of anthranilic acid with 4-(2-isothiocyanatoethyl)benzenesulfonamide in ethanol containing trimethylamine gave 4-(2-(2-mercapto-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamide (1) [55 (link),59 (link)]. Melting points (uncorrected) were recorded on a Barnstead 9100 Electrothermal melting apparatus (APS Water Services Corporation, Van Nuys, CA, USA). In contrast, the KBr disc IR spectra are recorded on an FT-IR Perkin-Elmer spectrometer (PerkinElmer Inc., Waltham, MA, USA). The ¹H NMR and ¹³C NMR were measured in DMSO-d₆ on Bruker 700 and 176 MHz instruments, respectively (Bruker, Billerica, MA, USA). Supporting Information: ¹H NMR and ¹³C NMR of compounds 2–27. Mass spectra were recorded on an Agilent 6320 Ion Trap mass spectrometer (Agilent Technologies, Santa Clara, CA, USA). C, H, and N were analyzed at the Research Centre, College of Pharmacy, King Saud University, Saudi Arabia. The results were within ±0.4% of the theoretical values.