Protocol detail

IFNAR1 Blocking Antibody in Infection

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The IFN receptor (IFNAR1) blocking mAb MAR1-5A3 or isotype control (Bio X Cell) was administered by a single intraperitoneal injection of 2.5 mg mAb the day before infection with B. burgdorferi or the administration of K/B×N serum, Figs 2, 9 (20 (link), 37 (link)).

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Ma Y., Bramwell K.K., Lochhead R.B., Paquette J.K., Zachary J.F., Weis J.H., Teuscher C, & Weis J.J. (2014). Borrelia burgdorferi arthritis associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of Type I IFN production. Journal of immunology (Baltimore, Md. : 1950), 193(12), 6050-6060.

Publication 2014

MAR1-5A3 isotype control

Cell Figs Infection Intraperitoneal injection Isotype Mar1 Serum

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Variable analysis

independent variables

Administration of IFN receptor (IFNAR1) blocking mAb MAR1-5A3
Administration of isotype control

dependent variables

Infection with B. burgdorferi
Administration of K/B×N serum

control variables

Single intraperitoneal injection of 2.5 mg mAb the day before infection or administration of K/B×N serum

controls

Positive control: Isotype control (Bio X Cell)
Negative control: Not explicitly mentioned

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