Mycobacterium tuberculosis Susceptibility Testing

Drug susceptibility was determined using the 1% proportion method on L–J medium according to the guidelines of the WHO [10 (link)], with rifampin (RIF), 40 μg/ml; isoniazid (INH), 0.2 μg/ml; streptomycin (SM), 10 μg/ml; ethambutol (EMB), 2 μg/ml; capreomycin (CM), 40 μg/ml; kanamycin (KM), 30 μg/ml; ofloxacin (OFX), 2 μg/ml; amikacin (AM). The MDR-TB was defined as resistance to at least INH and RIF. Extensively drug-resistant tuberculosis (XDR-TB) isolates were defined as MDR-TB isolates with additional resistance to both OFX and KM [11 (link)].

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Hu Y., Fan J., Zhu D., Liu W., Li F., Li T, & Zheng H. (2023). Investigation of bedaquiline resistance and genetic mutations in multi-drug resistant Mycobacterium tuberculosis clinical isolates in Chongqing, China. Annals of Clinical Microbiology and Antimicrobials, 22, 19.

Publication 2023

Amikacin Capreomycin Drug Ethambutol Kanamycin Ofloxacin Rifampin Streptomycin Susceptibility Xdr tb

Corresponding Organization : Chongqing Public Health Medical Center

Other organizations : Center for Tuberculosis Control of Guangdong Province, Beijing Children’s Hospital, Capital Medical University

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Variable analysis

independent variables

Rifampin (RIF), 40 μg/ml
Isoniazid (INH), 0.2 μg/ml
Streptomycin (SM), 10 μg/ml
Ethambutol (EMB), 2 μg/ml
Capreomycin (CM), 40 μg/ml
Kanamycin (KM), 30 μg/ml
Ofloxacin (OFX), 2 μg/ml
Amikacin (AM)

dependent variables

Drug susceptibility

control variables

1% proportion method on L–J medium

controls

Positive control: Not specified
Negative control: Not specified

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