CT imaging was acquired with a dual-source CT scanner (Siemens Somatom Force, Siemens AG, München, Germany) using the following parameters: 120 kVp tube voltage; 0.5 s gantry rotation; and 5 mm reconstruction thickness. A senior HPB fellow conducted a volumetric analysis using the IntelliSpace Portal 8.0 software tool (Philips healthcare, Amsterdam, The Netherlands). Total liver volume (TLV), tumor volume (TV) and FLR were subsequently computed by the program after manual delineation of margins in every slide. In each of these calculations, TV was considered to be non-functional. The calculated FLR (cFLR) was then computed as described before [10 (link)]. Hypertrophy was defined as a proportional increase in cFLR. Patients displaying a hypertrophy of less than 25% were defined as non-responders.
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