The following histologic data were analyzed: diagnosis rendered by the Pathology Committee (i.e. “not steatohepatitis”, “borderline, zone 3 pattern”, “definite steatohepatitis”); the aggregate NAS; the score of each component of the NAS (steatosis (0–3), lobular inflammation (0–3), ballooning (0–2)), and fibrosis scores (0,1a,1b,1c,2,3). In addition, portal chronic inflammation and steatosis location were included. The "borderline zone 3 pattern" was reserved for biopsies that have zone 3 accentuation of lesions, but not all the lesions for definite steatohepatitis were present. This definition is purposely left broad so as to neither preclude further evaluation nor include the biopsies in the "not SH" category.
Protocol detail
Histologic Evaluation of Steatohepatitis
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Corresponding Organization :
Other organizations : Washington University in St. Louis, National Cancer Institute, Johns Hopkins University, Saint Louis University
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Variable analysis
independent variables
- Diagnosis rendered by the Pathology Committee (i.e. "not steatohepatitis", "borderline, zone 3 pattern", "definite steatohepatitis")
- The aggregate NAS
- The score of each component of the NAS (steatosis (0–3), lobular inflammation (0–3), ballooning (0–2))
- Fibrosis scores (0,1a,1b,1c,2,3)
- Portal chronic inflammation
- Steatosis location
- Not explicitly mentioned
- No positive or negative controls were specified in the provided information.
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