Drugs for this study were purchased in solid powder form Selleck Chem, Houston, TX, United States (BPTES, Sulfasalazine, Rapamycin A769662, SnMP, P7C3, Etomoxir, BSO, GSK2194069). AGI15280, AGI-519 and GNE-140 were purchased from Adooq Bioscience. All metabolites were purchased in solid powder form from Sigma-Aldrich.
Drugs and metabolites were formulated with 8,000 g/mol molecular weight polyethylene glycol (PEG) (Polysciences, Inc.) into a 25% w/w drug-PEG-8000 composite powder and were loaded into micro-reservoirs as described in (Jonas et al., 2015 (link)). Drugs are chosen based on specific role in the immune and/or cancer metabolism.
Drugs and metabolites were formulated with 8,000 g/mol molecular weight polyethylene glycol (PEG) (Polysciences, Inc.) into a 25% w/w drug-PEG-8000 composite powder and were loaded into micro-reservoirs as described in (Jonas et al., 2015 (link)). Drugs are chosen based on specific role in the immune and/or cancer metabolism.
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