Data is acquired with the same spiral trajectory as the numerical phantom, with matrix size 60 × 60 with 256 temporal frames [14 (link)]. A healthy volunteer was scanned at a Siemens 3T scanner with a 12 channel receiver headcoil. Eight fat saturation bands were used to suppress extra cranial lipids. The first repetition of the sequence is used to acquire water reference data. An axial slice of FOV= 240 mm2 was collected at TR/TE = 1500/55 ms and the scan time was 7.2 mins to collect 12 averages. The water data was processed to obtain high resolution field inhomogeneity maps and lipid and brain masks that characterize the spatial compartments as described in [17 (link)].