Venous blood was collected on enrollment for standard hematology and biochemistry. Peripheral blood parasitemia was assessed by research microscopists on enrollment and every 6 hours until 2 consecutive negative smears were obtained. Serum creatinine was measured on enrollment and then every 12 hours until 72 hours, then at 7 and 28 days. Creatinine was measured in real time at the accredited enrolling hospitals using an automated modified Jaffe alkaline picrate method (Architect c8000 Chemistry Analyzer, Abbot), with the assay traceable to the Isotope dilution mass spectrometry (IDMS) standard. Urine microalbumin was measured on fresh midstream urine (Clinitek 50, Bayer). CFHb was measured at enrollment, at 12 hours, and then daily for 72 hours using enzyme-linked immunosorbent assay (Bethyl Laboratories) on twice-centrifuged citrated plasma. Liver function tests (LFTs) and urine albumin-to-creatinine ratio (ACR) were measured at 0 and 72 hours and at 7 and 28 days. Plasma acetaminophen concentrations were measured using liquid chromatography-mass spectrometry as previously described [26 (link)], detailed in the Supplementary Materials.