Recombinant DNA Protocols and Plasmid Isolation
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Corresponding Organization : Norwegian University of Science and Technology
Variable analysis
- Recombinant DNA procedures performed as described by Sambrook and Russell
- DNA extraction methods (QIAquick gel extraction kit, QIAquick PCR purification kit)
- Plasmid DNA isolation methods (Wizard Plus SV Minipreps DNA purification kit, NucleoBond Xtra Midi kit)
- Synthetic oligonucleotides ordered from Sigma-Aldrich or Eurofins
- Restriction cloning performed according to New England Biolabs recommendations
- PCR reactions carried out with Expand High Fidelity PCR System or Q5 High-Fidelity DNA Polymerase
- Escherichia coli transformation using modified RbCl protocol
- Pseudomonas putida KT2440 transformation using electroporation protocol
- DNA fragment extraction
- Plasmid DNA isolation
- Transformation efficiency of E. coli and P. putida
- Plasmid sequence confirmation
- Recommendations and protocols provided by the manufacturers of the commercial kits and enzymes used
- Protocols described in the referenced publications (Sambrook and Russell, Hanahan et al.)
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