Protocol detail

Intracochlear Sound Pressure Measurement

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The method used for intracochlear sound pressure measurement is described in detail in a previous publication^{16 (link)}. Here, sound pressure in SV (P_SV) and ST (P_ST) was recorded simultaneously with fiber-optic pressure transducers with a diameter of 310 µm (FOP-M260, FISO Technologies, Canada) connected to a two-channel signal conditioner (Veloce 50, FISO Technologies, Canada). Transducers were inserted 100–300 µm (visually estimated) into both scalae through fenestrations of approx. 0.4 mm diameter and sealed with a 3 mm piece of silicone tube (Sedat, France) permanently mounted to the optical fiber and dental impression material alginate (Alginoplast®, Heraeus Kulzer GmbH, Germany) (Fig. 1). Phases of the pressure transducers were calibrated in air against a 1/4” reference microphone (Type 4939, Brüel & Kjær, Denmark) and amplitudes against a probe microphone (ER-7C, Etymotic Research Inc., USA). The ICPD (ΔP) was calculated as the vector difference of P_SV and P_ST in the frequency domain.Figure 1

Temporal bone preparation for the incus stimulation. The tip of the T2 actuator was attached to the incus body and the FISO FOP-M260 transducers were inserted in scala vestibuli (SV) and scala tympani (ST) next to the round window membrane (RWM).

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Grossöhmichen M., Waldmann B., Salcher R., Prenzler N., Lenarz T, & Maier H. (2017). Validation of methods for prediction of clinical output levels of active middle ear implants from measurements in human cadaveric ears. Scientific Reports, 7, 15877.

Publication 2017

Alginoplast®, Type 4939 ER-7C

Alginate Body Bone Dental impression material Fenestrations Incus Membrane Pressure Pressure transducers Round window Scala tympani Scala vestibuli Silicone Sound Sound measurement Transducers Vector

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Variable analysis

independent variables

Sound pressure in scala vestibuli (P_SV)
Sound pressure in scala tympani (P_ST)

dependent variables

Intracochlear pressure difference (ICPD, ΔP)

control variables

Diameter of fiber-optic pressure transducers (310 μm)
Insertion depth of transducers (100-300 μm)
Diameter of fenestrations (approx. 0.4 mm)
Sealing of transducers with silicone tube and dental impression material
Calibration of transducer phases in air against a reference microphone
Calibration of transducer amplitudes against a probe microphone

positive controls

Not explicitly mentioned

negative controls

Not explicitly mentioned

Annotations

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