Multimodal MRI Acquisition for Neuroscience

We acquired imaging data at the Athinoula A. Martinos Center for Biomedical Imaging at MIT with a Siemens Magnetom Trio 3-tesla scanner with a 32-channel phased-array head coil. T1-weighted structural images were collected using the magnetization-prepared rapid acquisition gradient echo (MPRAGE) sequence (TR = 2530 ms; TE = 1.64–7.22 ms; TI = 1400 ms; flip angle = 7°; 1 × 1 × 1-mm³ isotropic voxels; matrix size: 256 × 256; 172 slices). Whole-brain diffusion-weighted images were collected with a spin-echo echo-planar sequence (TR = 8420 ms; TE = 84 ms; 2 × 2 × 2 mm³ isotropic voxels; matrix size: 128 × 128; 67 slices). This included 60 gradient orientations at b = 700 s/mm² and 10 no-diffusion images (b = 0). Sixty-two volumes of eyes-open resting state data were collected with a 6 s TR. As with the diffusion images, the resting state matrix size was 128 × 128 × 67 with 2 × 2 × 2 mm³ isotropic voxels. T1 and diffusion data from these subjects were previously published (Cai et al., 2014 (link)). Resting state data were collected from the same subjects in the same MRI sessions.

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Sitek K.R., Cai S., Beal D.S., Perkell J.S., Guenther F.H, & Ghosh S.S. (2016). Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering. Frontiers in Human Neuroscience, 10, 190.

Publication 2016

Magnetom Trio 3-tesla scanner 32-channel phased-array head coil

Brain Diffusion Echo Eyes Head Orientations Trio

Corresponding Organization :

Other organizations : Harvard University, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Boston University, University of Toronto, Holland Bloorview Kids Rehabilitation Hospital

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Variable analysis

independent variables

Imaging modality (T1-weighted structural, diffusion-weighted, resting-state)

dependent variables

T1-weighted structural images
Whole-brain diffusion-weighted images
Resting-state data

control variables

Siemens Magnetom Trio 3-tesla scanner
32-channel phased-array head coil
MPRAGE sequence parameters (TR, TE, TI, flip angle, voxel size, matrix size, number of slices)
Spin-echo echo-planar sequence parameters for diffusion-weighted images (TR, TE, voxel size, matrix size, number of slices, number of gradient orientations, b-values)
Resting-state sequence parameters (TR, matrix size, voxel size, number of volumes)

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