Analgesic Pharmacology in K/BxN Arthritis

To define the analgesic pharmacology of the K/BxN allodynic state, groups of 16-week-old K/BxN transgenic arthritic mice (n = 6/sex) received a single i.p. injection of gabapentin (100 mg/kg; Pfizer), or the NSAID, ketorolac (7.5 mg/kg; Sigma). Mice were measured for changes in tactile allodynia 1 h following treatment. Drugs were allowed to wash out for 48 h before the same procedure was repeated with a different drug. gabapentin^{50 (link),51 (link)}, and ketorolac^{24 (link)} were dissolved in normal saline, dosages were based on previous reports demonstrating anti-allodynic efficacy, absent motor or general behavioral effects, in murine models of mono / poly and inflammatory neuropathy, respectively.

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Gonçalves dos Santos G., Jimenéz-Andrade J.M., Woller S.A., Muñoz-Islas E., Ramírez-Rosas M.B., Ohashi N., Ferreira Catroli G., Fujita Y., Yaksh T.L, & Corr M. (2020). The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling. Scientific Reports, 10, 15596.

Publication 2020

gabapentin ketorolac

Allodynic Analgesic Drug Gabapentin Inflammatory Ketorolac Mice Murine Normal saline Nsaid Poly Tactile allodynia Transgenic mice

Corresponding Organization :

Other organizations : University of California, San Diego, Autonomous University of Tamaulipas

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Variable analysis

independent variables

Gabapentin (100 mg/kg; Pfizer)
Ketorolac (7.5 mg/kg; Sigma)

dependent variables

Changes in tactile allodynia 1 h following treatment

control variables

16-week-old K/BxN transgenic arthritic mice (n = 6/sex)
Drugs were allowed to wash out for 48 h before the same procedure was repeated with a different drug

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

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