Creatinine, eGFR, and CRP Measurements

Serum creatinine measurements were performed on a Roche Modular Analyser using a blank rated compensated Jaffe reaction, and eGFR was estimated using the creatinine-based CKD-EPI equation^{33 (link)}. Urinary creatinine was measured using the ADVIA 1800 Chemistry System (Bayer HealthCare). Urinary ACR was measured using a Roche Hitachi 702 analyser. C-reactive protein (CRP) was measured using the Full Range C-Reactive Protein Kit on a SPA^TM automated PLUS turbidimeter (The Binding Site Group Ltd, UK). The normal range for CRP is between 0.1 and 9 mg/L, with 90 percent below 3 mg/L^{34 (link)}.

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Rasmussen D.G., Fenton A., Jesky M., Ferro C., Boor P., Tepel M., Karsdal M.A., Genovese F, & Cockwell P. (2017). Urinary endotrophin predicts disease progression in patients with chronic kidney disease. Scientific Reports, 7, 17328.

Publication 2017

Modular Analyser ADVIA 1800 Chemistry System

Binding site C reactive protein Creatinine Egfr Serum Urinary

Corresponding Organization : Nordic Bioscience (Denmark)

Other organizations : Queen Elizabeth Hospital Birmingham, RWTH Aachen University, University of Southern Denmark, University of Birmingham

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Variable analysis

independent variables

Serum creatinine measurements

dependent variables

Estimated Glomerular Filtration Rate (eGFR)
Urinary creatinine
Urinary Albumin-to-Creatinine Ratio (ACR)
C-reactive protein (CRP)

control variables

Serum creatinine measurements were performed on a Roche Modular Analyser using a blank rated compensated Jaffe reaction
Urinary creatinine was measured using the ADVIA 1800 Chemistry System (Bayer HealthCare)
Urinary ACR was measured using a Roche Hitachi 702 analyser
CRP was measured using the Full Range C-Reactive Protein Kit on a SPA™ automated PLUS turbidimeter (The Binding Site Group Ltd, UK)
The normal range for CRP is between 0.1 and 9 mg/L, with 90 percent below 3 mg/L

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