Transcriptome Analysis of Cervical Cancer

RNAseq data in the transcripts per million (TPM) format from The Cancer Genome Atlas (TCGA) (https://portal.gdc.cancer.gov/) and The Genotype-Tissue Expression (GTEx) (https://gtexportal.org/) were uniformly processed using the Toil process (20 (link)). Through extraction of the cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) data in TCGA and corresponding normal tissue data in GTEx, the 306 cervical tumor samples were classified as the malignant group and the three samples adjacent to cancer from TCGA together with the 10 normal cervix tissues from GTEx were classified as the non-malignant group. The RNAseq data in TPM format were log2 transformed for expression comparison between samples.

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Yang X, & Zhu W. (2023). ERBB3 mediates the PI3K/AKT/mTOR pathway to alter the epithelial‑mesenchymal transition in cervical cancer and predict immunity filtration outcome. Experimental and Therapeutic Medicine, 25(4), 146.

Publication 2023

Adenocarcinoma Cancer Cervical Cervical tumor Cervix Endocervical Genome Genotype Squamous cell carcinoma Tissue

Corresponding Organization :

Other organizations : Soochow University, Second Affiliated Hospital of Soochow University

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Expression of genes in cervical tumor samples (malignant group) and normal cervix tissues (non-malignant group)

control variables

Three samples adjacent to cancer from TCGA
10 normal cervix tissues from GTEx

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