The oral tobacco product chosen was Camel snus (Winterchill and Robust, 2.5 and 2.6 mg nicotine/pouch, respectively, distributed by Reynolds American Inc). These snus products were chosen because of the higher levels of unprotonated nicotine in them compared to other US manufactured snus products and prior research showing that suppression of smoking is greater with oral non-combusted products with higher nicotine levels.17 (link) Participants who experienced adverse effects from these doses were provided Frost or Mellow (1.5 and 1.3 mg nicotine/pouch, respectively). A Swedish snus product with even higher levels of nicotine may have been preferable to compare with the Swedish experience. However, our prior preference study showed that no smoker chose the Swedish snus (General Snus).17 (link) Nicotine gum (4 mg Nicorette distributed by GlaxoSmithKline) was chosen as the medicinal nicotine product, and participants who experienced adverse effects were down-titrated to 2 mg Nicotine gum.
Protocol detail
Oral Tobacco Products for Smoking Cessation
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Other organizations : University of Minnesota, Oregon Research Institute, University of Minnesota Medical Center
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Variable analysis
independent variables
- Oral tobacco product (Camel snus Winterchill and Robust, with 2.5 and 2.6 mg nicotine/pouch, respectively)
- Nicotine gum (4 mg Nicorette)
- Suppression of smoking
- Frost or Mellow snus (1.5 and 1.3 mg nicotine/pouch, respectively) used for participants experiencing adverse effects from higher nicotine doses
- Camel snus Winterchill and Robust with higher levels of unprotonated nicotine compared to other US-manufactured snus products
- Swedish snus (General Snus) was not chosen for the study due to prior preference study showing no smoker choosing it
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