Comparative Transcriptomics Across Species

H. sapiens PHTF1 and PHTF2 tissue-specific RNA expression data were obtained from the GTEx Portal (GTEx Analysis Release V8 [dbGaP Accession phs000424.v8.p2; https://gtexportal.org/home/datasets]). Tissue/life stage-specific RNA expression data of Phtf and Grl genes in D. melanogaster were downloaded from the Fly Atlas 2.0 (https://motif.mvls.gla.ac.uk/FlyAtlas2) (Krause et al., 2022 (link)) or, for the labellum, from Dweck et al., 2021 (link). D. melanogaster scRNA-seq data was from the Fly Cell Atlas (Li et al., 2022 (link)): proboscis/maxillary palp (10× stringent dataset) and testis/seminal vesicle (10× relaxed dataset), visualized as HVG tSNE or UMAP plots, respectively, in the SCope interface (https://scope.aertslab.org/#/FlyCellAtlas) (Davie et al., 2018 (link)).

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Benton R, & Himmel N.J. (2023). Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins. eLife, 12, e85537.

Publication 2023

Cell D melanogaster Genes Maxillary Rna expression Scrna seq Seminal vesicle Testis Tissue

Corresponding Organization :

Other organizations : New York University, University of Lausanne

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Variable analysis

independent variables

H. sapiens PHTF1 and PHTF2 tissue-specific RNA expression data
Phtf and Grl tissue/life stage-specific RNA expression data in D. melanogaster
D. melanogaster scRNA-seq data from the Fly Cell Atlas: proboscis/maxillary palp and testis/seminal vesicle

dependent variables

Tissue-specific RNA expression levels of H. sapiens PHTF1 and PHTF2
Tissue/life stage-specific RNA expression levels of Phtf and Grl genes in D. melanogaster
ScRNA-seq data from D. melanogaster proboscis/maxillary palp and testis/seminal vesicle

control variables

Control variables not explicitly mentioned.

positive controls

No positive controls specified.

negative controls

No negative controls specified.

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