From March 1995 till now, the Taiwan national health insurance (NHI) program has covered 99.6% of residents. All medical records reimbursed by the NHI were included in the NHIRD, in which the registry of beneficiaries, ambulatory and inpatient care claims data, and the registry of catastrophic illness were the source of the database. In the study, study subjects were recruited from the ambulatory and inpatient claims data liked with the registry of Catastrophic Illness during 2000 to 2010 and followed to the end of 2011.
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