Evaluation of Febrile Infants for Bacterial Infection

This was a prospective observational study that included 22 emergency departments (EDs) in the Pediatric Emergency Care Applied Research Network (PECARN). A convenience sample of infants aged 60 days or younger were evaluated for fever (rectal temperatures >38° C documented in the ED, home, or clinic). Those who underwent laboratory evaluations that included at least 1 blood culture were enrolled. Febrile infants presenting to any of the 22 EDs when study research staff members were available were screened for study eligibility. The parents or guardians of eligible infants were approached, and their infants were enrolled upon receiving written informed consent. The study was approved by the institutional review boards at all sites. For this preliminary analysis, a random sample of enrolled infants was selected (described below).
The goal was to focus on infants who posed diagnostic quandaries; therefore, infants with clinical sepsis, prematurity, significant comorbidities, focal bacterial infections (except otitis media), and those already receiving antibiotics were excluded. Laboratory evaluations, aside from blood cultures and blood draws for RNA biosignatures, were performed at the treating physician’s discretion and typically included white blood cell counts, urinalyses and urine cultures, and CSF analyses and cultures. Based on culture results, febrile infants were assigned either to the bacterial infection group (bacteremia, UTI, bacterial meningitis) or to the without-bacterial-infection group.

Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link: Access Free Full Text.

Mahajan P., Kuppermann N., Mejias A., Suarez N., Chaussabel D., Casper T.C., Smith B., Alpern E.R., Anders J., Atabaki S.M., Bennett J.E., Blumberg S., Bonsu B., Borgialli D., Brayer A., Browne L., Cohen D.M., Crain E.F., Cruz A.T., Dayan P.S., Gattu R., Greenberg R., Hoyle JD J.r., Jaffe D.M., Levine D.A., Lillis K., Linakis J.G., Muenzer J., Nigrovic L.E., Powell E.C., Rogers A.J., Roosevelt G., Ruddy R.M., Saunders M., Tunik M.G., Tzimenatos L., Vitale M., Dean J.M, & Ramilo O. (2016). Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger. JAMA, 316(8), 846-857.

Publication 2016

Antibiotics Bacteremia Bacterial infection Bacterial meningitis Blood cultures Blood draws Diagnostic Eligibility Febrile Guardians Infants Institutional review boards Otitis media Parents Physician Prematurity Rectal Sepsis Urinalyses Urine White blood cell counts Younger

Corresponding Organization : The Ohio State University

Other organizations : Wayne State University, Children's Hospital of Michigan, University of California, Davis, Sidra Medical and Research Center, University of Utah, Northwestern University, Lurie Children's Hospital, Children's Hospital of Philadelphia, Johns Hopkins University, Children's National, Alfred I. duPont Hospital for Children, DuPont (United States), Nemours Children's Health System, Jacobi Medical Center, Hurley Medical Center, University of Michigan–Flint, University of Rochester Medical Center, Children's Hospital of Wisconsin, Medical College of Wisconsin, Texas Children's Hospital, Baylor College of Medicine, Columbia University, University of Maryland, Baltimore, University of Maryland Medical Center, Primary Children's Hospital, Stryker (United States), Spectrum Health, Western Michigan University, Helen DeVos Children's Hospital, Corewell Health Blodgett Hospital, St. Louis Children's Hospital, University of California, San Francisco, Bellevue Hospital Center, New York University, University at Buffalo, State University of New York, Women & Children's Hospital of Buffalo, Hasbro Children's Hospital, Brown University, Phoenix Children's Hospital, Boston Children's Hospital, Harvard University, University of Michigan–Ann Arbor, Children's Hospital Colorado, University of Colorado Denver, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Children's Hospital of Pittsburgh, University of Pittsburgh

Top 5 similar protocols

Protocol cited in 8 other protocols

Variable analysis

independent variables

None explicitly mentioned

dependent variables

Presence of bacterial infection (bacteremia, UTI, bacterial meningitis)

control variables

Exclusion of infants with clinical sepsis, prematurity, significant comorbidities, focal bacterial infections (except otitis media), and those already receiving antibiotics

controls

No positive or negative controls were explicitly mentioned in the information provided.

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!