Measuring Neurofilament Light Levels

cNfL was analyzed using a sensitive sandwich enzyme-linked immunosorbent assay (ELISA) method (NF-light^® ELISA kit; UmanDiagnostics AB, Umea, Sweden; catalogue # 10-7001 CE) and age-adjusted upper limits of the reference range utilized in clinical practice were used in order to determine whether cNfL levels were elevated or normal, as previously described (28 (link)). These upper limits are: <380 ng/L (<30 years), <560 ng/L (30-39 years), <890 ng/L (40-60 years), and <1850 ng/L (>60 years).

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Rosenstein I., Rasch S., Axelsson M., Novakova L., Blennow K., Zetterberg H, & Lycke J. (2022). Increased intrathecal neurofilament light and immunoglobulin M predict severe disability in relapsing-remitting multiple sclerosis. Frontiers in Immunology, 13, 967953.

Publication 2022

NF-light® ELISA kit

Enzyme linked immunosorbent assay Light

Corresponding Organization : University of Gothenburg

Other organizations : Sahlgrenska University Hospital, UK Dementia Research Institute, University College London, National Hospital for Neurology and Neurosurgery

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

CNfL levels

control variables

Age-adjusted upper limits of the reference range utilized in clinical practice

controls

None mentioned
None mentioned

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