The chemical structure of SDX-7320 is shown in Fig. 1 , along with the pharmacologically active small molecule METAP2 inhibitor SDX-7539. The preparation and characterization of SDX-7320 and SDX-7539 are described in the Supplementary Data and in Supplementary Fig. S1 and Supplementary Table S1, along with the related compounds SDX-9246, SDX-9280, SDX-9178, TNP-470, and CKD-732. The benzenesulfonic acid salt form of SDX-7539 (SDX-9402) was used for in vitro experiments.
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Synthesis and Characterization of METAP2 Inhibitors
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Corresponding Organization :
Other organizations : SynDevRx (United States), BioVentures (United States)
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Variable analysis
independent variables
- Preparation and characterization of SDX-7320
- Preparation and characterization of SDX-7539
- Related compounds SDX-9246, SDX-9280, SDX-9178, TNP-470, and CKD-732
- In vitro experiments using the benzenesulfonic acid salt form of SDX-7539 (SDX-9402)
- Not explicitly mentioned
- Positive control: Not mentioned
- Negative control: Not mentioned
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