Quantitative CT Analysis of Emphysema and Airways

Image analysis on all CT exams was performed using Pulmonary Workstation Plus software (VIDA Diagnostics, Inc., Coralville, IA). Automated segmentation of the right and left lungs from the chest wall and mediastinum was performed. The virtual airway tree was generated using an automated region-growing technique and detailed airway analysis to the subsegmental bronchi in six selected airway paths (RB1, RB4, RB10, LB1, LB4 & LB10) was performed. The wall area % (bronchial wall area as percentage of total bronchial area) was calculated for segmental and subsegmental bronchi. For each patient, % emphysema was defined as % lung voxels less than or equal to −950 Hounsfield units (HU) on inspiratory CT, and % gas trapping was defined as % lung voxels less than or equal to −856 HU on expiratory CT. In the 49 normal subjects, the 90^th percentile for wall area %, % emphysema, and % gas trapping were identified.

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Lynch D.A., Murphy J.R., Crapo J.D., Criner G.J., Galperin-Aizenberg M., Jacobson F.L., Lipson D.A., Mamary A.J., Newell JD J.r., Sharafkhaneh A, & van Beek E.J. (2012). A combined pulmonary -radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD, 9(2), 151-159.

Publication 2012

Bronchi Chest wall Diagnostics Emphysema Expiratory Inspiratory Lung Mediastinum Patient Tree

Corresponding Organization :

Other organizations : University of Colorado Denver, University of Edinburgh

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Wall area % (bronchial wall area as percentage of total bronchial area)
% emphysema (% lung voxels less than or equal to −950 Hounsfield units (HU) on inspiratory CT)
% gas trapping (% lung voxels less than or equal to −856 HU on expiratory CT)

control variables

Automated segmentation of the right and left lungs from the chest wall and mediastinum
The virtual airway tree was generated using an automated region-growing technique
Detailed airway analysis to the subsegmental bronchi in six selected airway paths (RB1, RB4, RB10, LB1, LB4 & LB10)

controls

None explicitly mentioned

Annotations

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