Comprehensive Neural Interaction Database

NeuronChatDB is curated from existing databases (including KEGG^{53 (link)} and IUPHAR/BPS Guide to PHARMACOLOGY^{54 (link)}) and literature (e.g., neuropeptide interactions are from the reference^{16 (link)}), and contains neural-specific intercellular molecular interactions for both mouse and human. There are 373 entries in total. Each entry of NeuronChatDB represents an interaction pair, including one ligand and a cognate target as well as genes related to them. The ligands include small-molecule neurotransmitters, neuropeptides, gap junction proteins, gasotransmitters and synaptic adhesion molecules: small-molecule neurotransmitters include glutamate (Glu), GABA, glycine (Gly), acetylcholine (ACh), serotonin (5-HT), dopamine (DA), epinephrine (Epi) and norepinephrine (NE); gasotransmitters include carbon monoxide (CO) and Nitric oxide (NO); synaptic adhesion molecules refer to neurexins (regarded as the ligand) and neuroligins (regarded as the target). The targets are typically but not limited to receptors. For example, the target proteins for neurotransmitters can also be uptake transporters or deactivating enzymes; the target proteins for gap junction proteins are other compatible gap junction proteins. For non-peptide neurotransmitters, corresponding synthesizing enzymes and/or vesicular transporters are included in the entry; for heteromeric receptors that contain multiple different subunits, corresponding subunits are split into different entries with the same ligand. To be compatible with the inference model of NeuronChat, for the non-peptide neurotransmitters, related genes including vesicular transporters and synthesizing enzymes responsible for different catalyzing steps are annotated into separate groups.