We conducted a retrospective clinical study involving 57 patients who were first diagnosed with NFPA and received tumor resection by endoscopic sphenoidal sinus surgery at the Affiliated Hospital of Guangdong Medical University from January 2020 to April 2022. All surgeries were done by the same experienced neurosurgeon and reasonable optic apparatus decompression was accomplished following tumor removal. Intraoperatively, the structure of the ultra care was paid to preserve relevant sellar/suprasellar neurovascular structures, and achieve adequate hemostasis to avoid postoperative compressing hematoma. Overfilling with skull base reconstructive materials was avoided to prevent optic apparatus compression. Fifty-three healthy subjects with matching average gender and age as the controls. All subjects underwent examination of best-corrected visual acuity (BCVA) and the visual field, OCT of the optical disk and macular, and DTI of the visual pathway.
The inclusion and exclusion criteria for the NFPA group were as follows. I. PA was indicated by plain MRI and enhanced examination of the brain. II. PA was the first complete resection obtained by endoscopic sphenoidal sinus surgery by the same brain surgeon without additional optic nerve damage and was confirmed by histopathological examination. III. NFPA was clinically diagnosed in patients aged between 18 and 60 years. IV. Non-contact intraocular pressure was ≤21 mmHg (1 mmHg = 0.133 kPa). V. There was no previous history of intracranial diseases and trauma, intracranial surgery, ocular trauma, glaucoma, neuroretinal disease, or internal eye surgery. VI. Previous refractive errors were <±6.0D (spherical mirror) and <3.00D (column mirror). VII. The OCT images were clear, and the DTI images were of good quality.
The inclusion and exclusion criteria for the control group were as follows. I. Non-contact intraocular pressure was ≤21 mmHg. II. Visual acuity or corrected visual acuity was ≥ 0.6, and refractive errors were <± 6.0D (spherical mirror) and <3.00D (column mirror). III. There was no previous history of intracranial diseases, trauma, or intracranial surgery. IV. There was no history of ocular trauma, glaucoma, neuroretinal diseases, or internal eye surgery. V. The subjects’ age and sex-matched those of the NFPA group. VII. The OCT image was clear, and the DTI images were of good quality.
This study was conducted in accordance with the principles of the Helsinki Declaration and was approved by the Ethics Committee of the Affiliated Hospital of Guangdong Medical University (Approval Document No. PJ2020-006 and VJ2020-006-03). All subjects signed informed consent forms.
The inclusion and exclusion criteria for the NFPA group were as follows. I. PA was indicated by plain MRI and enhanced examination of the brain. II. PA was the first complete resection obtained by endoscopic sphenoidal sinus surgery by the same brain surgeon without additional optic nerve damage and was confirmed by histopathological examination. III. NFPA was clinically diagnosed in patients aged between 18 and 60 years. IV. Non-contact intraocular pressure was ≤21 mmHg (1 mmHg = 0.133 kPa). V. There was no previous history of intracranial diseases and trauma, intracranial surgery, ocular trauma, glaucoma, neuroretinal disease, or internal eye surgery. VI. Previous refractive errors were <±6.0D (spherical mirror) and <3.00D (column mirror). VII. The OCT images were clear, and the DTI images were of good quality.
The inclusion and exclusion criteria for the control group were as follows. I. Non-contact intraocular pressure was ≤21 mmHg. II. Visual acuity or corrected visual acuity was ≥ 0.6, and refractive errors were <± 6.0D (spherical mirror) and <3.00D (column mirror). III. There was no previous history of intracranial diseases, trauma, or intracranial surgery. IV. There was no history of ocular trauma, glaucoma, neuroretinal diseases, or internal eye surgery. V. The subjects’ age and sex-matched those of the NFPA group. VII. The OCT image was clear, and the DTI images were of good quality.
This study was conducted in accordance with the principles of the Helsinki Declaration and was approved by the Ethics Committee of the Affiliated Hospital of Guangdong Medical University (Approval Document No. PJ2020-006 and VJ2020-006-03). All subjects signed informed consent forms.
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