Meldonium Mitigates Hypoxia Effects

To evaluate the effect of pre-administrated with meldonium under acute high-altitude hypoxia, SD rats (6 in each group) were administered by gavage and randomly divided into normoxia group, hypoxia group (model group), hypoxia groups with differential dose meldonium (25, 50, 100, 200, and 400 mg/kg), and hypoxia with acetazolamide group (positive control). In addition, the pharmacokinetics of meldonium (25, 50, 100 mg/kg) was investigated under acute high-altitude hypoxia in SD rats administered by gavage and/or intravenously. Normoxia group rats given saline lived at an average altitude of 43.5 m, and the acute hypoxia groups were placed in a simulated hypobaric hypoxia chamber with an altitude of 7,000 m for 24 h after 3 days of continuous administration with meldonium.