Amygdala Stimulation Induced Temporal Lobe Epilepsy

The expression profile under the accession number GSE49850 (18 (link)) was downloaded from the public functional genomics data repository, Gene Expression Omnibus, which was based on the GPL17566 platform (miRCURY LNA microRNA array; Exiqon, Woburn, MA, USA). A total of 686 miRNAs in rats were analyzed in GSE49850. Data sets consisted of miRNA expression levels at 7, 14, 30 and 90 days subsequent to electrical stimulation of the amygdala, which was used as a model of temporal lobe epilepsy. The sham-operated time-matched control group (N) and the stimulated group (C) were included at each time point with 5 replicates of each.

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MENG F., YOU Y., LIU Z., LIU J., DING H, & XU R. (2014). Neuronal calcium signaling pathways are associated with the development of epilepsy. Molecular Medicine Reports, 11(1), 196-202.

Publication 2014

miRCURY LNA microRNA array

Amygdala Electrical stimulation Gene expression Mirna Rats Temporal lobe epilepsy

Corresponding Organization :

Other organizations : The Military General Hospital of Beijing PLA

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Variable analysis

independent variables

Electrical stimulation of the amygdala

dependent variables

MiRNA expression levels

control variables

Time points (7, 14, 30, and 90 days)
Sham-operated time-matched control group (N)
Stimulated group (C)

controls

Sham-operated time-matched control group (N)
Stimulated group (C)

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