Resagiline and Levodopa Combination Therapy

The control group received only levodopa and benserazide hydrochloride tablets: oral, 0.125 g/dose for the first dose, 3 times/d. After 1 week of continuous dosing, the dose was changed to 0.125 g 2. Per week (depending on the patient’s condition), and the maximum dose should not exceed 1.5 g in 1 day. The observation group was given the combination treatment of Resagiline + levodopa and benserazide hydrochloride tablets, in which the dose and regimen of levodopa and benserazide hydrochloride tablets were the same as above, and Resagiline was administered orally at 1 mg once daily. The duration of treatment for both groups was 1 year. In addition, patients in both groups were given the same routine rehabilitation training.

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Yang Y., Gao F., Gao L, & Miao J. (2023). Effects of rasagiline combined with levodopa and benserazide hydrochloride on motor function and homocysteine and IGF-1 levels in elderly patients with Parkinson’s disease. BMC Neurology, 23, 360.

Publication 2023

Benserazide Levodopa Patients Regimen Rehabilitation

Corresponding Organization : Southwest Jiaotong University

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Variable analysis

independent variables

Treatment group: Combination treatment of Resagiline + levodopa and benserazide hydrochloride tablets
Control group: Levodopa and benserazide hydrochloride tablets only

dependent variables

Patients' condition (which determined the dose changes)

control variables

Dose and regimen of levodopa and benserazide hydrochloride tablets (same for both groups)
Routine rehabilitation training (same for both groups)
Duration of treatment (1 year for both groups)

controls

Positive control: Control group receiving levodopa and benserazide hydrochloride tablets only
Negative control: Not mentioned

Annotations

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