Example 121
Rhodamine formamidine 175. 5-Aminorhodamine 174 (0.100 g, 0.249 mmol), (chloromethylene)dimethylimminium chloride (0.304 g, 2.49 mmol), and DIEA (0.50 mL, 2.87 mmol) were stirred in 4 mL of DMF for 16 h. The reaction mixture was evaporated and the crude product was purified on a silica gel column (1.5×25 cm bed, patched in MeCN/H2O/AcOH (8:2:2.5)), eluant: MeCN/H2O/AcOH (8:2:2.5) to give amidine 175 (0.050 g, 44%) as a red solid.
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