Ten-nanometer GNPs (MKN-Au-010; MK IPEX Corp, Divn MK Nano, Canada) with a spherical shape according to transmission electron microscopy (TEM) images were used in this study. The rats were intraperitoneally administered 50 µL of the 10 nm GNPs. The GNP dose was selected according to the results obtained in our previous studies,6 (link),7 (link) where we used 10, 20, and 50 nm GNPs and demonstrated that the smallest GNPs exhibited the highest toxicity in most of the organs of the rats, which was confirmed by histological investigations. Quercetin (Qur) and arginine (Arg) were purchased from Sigma-Aldrich Co. (St Louis, MO, USA). The Qur and Arg doses were 100 mg/kg body weight (BW)/day and 200 mg/kg BW/day, respectively, which were selected according to the previous studies.12 ,13 (link)
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Nanoparticle Toxicity Mitigation in Rats
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Other organizations : King Saud University, Astronomy and Space
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Variable analysis
independent variables
- Size of gold nanoparticles (GNPs): 10 nm, 20 nm, and 50 nm
- Toxicity of GNPs in different organs of rats
- Shape of GNPs: Spherical
- Route of administration: Intraperitoneal
- Dose of GNPs: 50 µL of 10 nm GNPs
- Dose of Quercetin (Qur): 100 mg/kg body weight (BW)/day
- Dose of Arginine (Arg): 200 mg/kg BW/day
- Not explicitly mentioned
- Not explicitly mentioned
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