DXA measurements for assessing bone mineral density and body composition parameters were performed at baseline and 12 months, using Hologic QDR-4500W instrumentation (Hologic Corporation, Waltham, Massachusetts). Data were analysed by a dedicated Endocrinologist (FM).
DXA measurements related to whole body DXA scans were extracted from Apex Software version 3.4.
The densitometric image of each patient was divided, following the manufacturer's instructions, into different body districts including arms, legs, trunk, head and other derived regions such as the android and gynoid zone.
BMD, BMC, fat free mass and fat mass were assessed for every region of interest, where fat free mass was provided by the software in terms of lean soft tissue plus bone mineral content (BMC). Despite the lean mass measured by DEXA counts also skin, connective tissue and some lean components within the adipose tissue [21 (link)], it still correlates highly with TC and MRI measurements and represents a good approximation of the real muscle mass [22 (link)].
Other DXA derived body composition parameters, such as fat mass index (FM/ H2) (FMI), appendicular lean mass index (ALM/H2) (ALMI) and Trunk/Appendicular ratio were then calculated to complete the analysis and the patient characterization.
DXA measurements related to whole body DXA scans were extracted from Apex Software version 3.4.
The densitometric image of each patient was divided, following the manufacturer's instructions, into different body districts including arms, legs, trunk, head and other derived regions such as the android and gynoid zone.
BMD, BMC, fat free mass and fat mass were assessed for every region of interest, where fat free mass was provided by the software in terms of lean soft tissue plus bone mineral content (BMC). Despite the lean mass measured by DEXA counts also skin, connective tissue and some lean components within the adipose tissue [21 (link)], it still correlates highly with TC and MRI measurements and represents a good approximation of the real muscle mass [22 (link)].
Other DXA derived body composition parameters, such as fat mass index (FM/ H2) (FMI), appendicular lean mass index (ALM/H2) (ALMI) and Trunk/Appendicular ratio were then calculated to complete the analysis and the patient characterization.
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