The inclusion criteria for this meta-analysis were as follows: Study design: randomized controlled trials (RCTs) comparing the effects of quantified versus willful grip exercises in PICC patients; Research population: patients with indwelling PICCs; Interventions: the experimental group underwent quantified grip exercises by designed nursing care plans, the control group underwent grip exercises at their own willingness; Observation indicators: The main indicators are the incidence of venous thrombosis and venous hemodynamics, and the secondary indicators are the infection rate associated to PICC. Venous thrombosis and venous blood flow velocity were examined with Doppler color ultrasound. The maximum venous blood flow velocity refers to the maximum blood flow velocity per second in the blood vessel. The exclusion criteria for this meta-analysis were: Replicated publications; Literature reports for which the full-text could not be obtained or the data could not be extracted.
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