Allostatic Load and Psychosocial Stress

The BPRHS is an ongoing longitudinal study that aims to examine the role of psychosocial stress on the presence and development of allostatic load (physiological dysregulation) and health outcomes such as depressive symptomatology, cognitive impairment, functional limitations, and metabolic conditions in Puerto Ricans. Further investigation includes the potential modification of these associations by nutritional status, especially for dietary fat, B vitamins and antioxidants, by genetic variation, and by sources and type of social and community support. The study was approved by the Institutional Review Board at Tufts Medical Center and Northeastern University. All participants provided written informed consent.

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Tucker K.L., Mattei J., Noel S.E., Collado B.M., Mendez J., Nelson J., Griffith J., Ordovas J.M, & Falcon L.M. (2010). The Boston Puerto Rican Health Study, a longitudinal cohort study on health disparities in Puerto Rican adults: challenges and opportunities. BMC Public Health, 10, 107.

Publication 2010

Antioxidants B vitamins Cognitive impairment Dietary fat Genetic variation Institutional review board Metabolic conditions Physiological Puerto ricans

Corresponding Organization :

Other organizations : Northeastern University, Tufts University, Boston University, Tufts Medical Center

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Variable analysis

independent variables

Psychosocial stress
Nutritional status (especially for dietary fat, B vitamins and antioxidants)
Genetic variation
Sources and type of social and community support

dependent variables

Allostatic load (physiological dysregulation)
Depressive symptomatology
Cognitive impairment
Functional limitations
Metabolic conditions

control variables

The study was approved by the Institutional Review Board at Tufts Medical Center and Northeastern University
All participants provided written informed consent

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