Murine IFNAR Knockout Model Study

Six- to eight-week-old male and female IFNAR^−/− (C57BL/6 mice homozygous for an IFNAR1 knock-out mutation, B6.129S2-Ifnar1^tm1Agt) [36 (link)] (bred in-house), WT BALB/c and C57BL/6 mice (purchased from Janvier Labs, France) were used throughout this study. All experiments using mice strictly followed Belgian guidelines for animal experimentation and guidelines of the Federation of European Laboratory Animal Science Associations (FELASA). The Ethical Committee of the Animal Research Center of KU Leuven approved all experiments (project number P100/2019).

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Ma J., Boudewijns R., Sanchez-Felipe L., Mishra N., Vercruysse T., Buh Kum D., Thibaut H.J., Neyts J, & Dallmeier K. (2021). Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice. Emerging Microbes & Infections, 10(1), 2279-2290.

Publication 2021

C57BL/6

C57bl mice European Female Homozygous Male Mice Mutation P100

Corresponding Organization : Global Virus Network

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Variable analysis

independent variables

Mouse type (IFNAR-/-, WT BALB/c, WT C57BL/6)

dependent variables

Not explicitly mentioned

control variables

Age (six- to eight-week-old)
Sex (male and female)
Experimental guidelines (Belgian guidelines for animal experimentation and guidelines of the Federation of European Laboratory Animal Science Associations (FELASA))
Ethical approval (Ethical Committee of the Animal Research Center of KU Leuven)

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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