Cardiovascular Function Prediction Protocol

Clinically, PH diagnosis requires invasive measurements of pulmonary blood pressure by RHC. These measurements are typically combined with systolic and diastolic systemic arterial pressure and cardiac output measurements. These measurements describe arterial dynamics but lack detailed information related to ventricular function. Our model predicts pressure, flow and volume in each compartment, augmenting information obtained from measurements. By combining these predictions, we can gain additional insight into the state of the cardiovascular system. Specifically, we compute:

(i)

Stroke work refers to the integral of the pressure–volume loop∫Vp(t) dV′,for each heart chamber. This is a clinical measure of ventricular function [9 (link),23 (link),24 (link)]. We convert stroke work to Joules (J) using the conversion that 1 J = 7.5 × 10³ mmHg ml.

(ii)

Resistance ratio: the pulmonary and systemic resistance ratio is defined as R_p/R_s (non-dimensional) [23 (link)].

(iii)

Compliance ratio of pulmonary and systemic arterial compliance, C_pa/C_sa (non-dimensional).

(iv)

Pulsatility index (PI) refers to to the ratio of pulmonary arterial pulse pressure to average right atrial pressure, (pM,pa−pm,pa)/p¯ra [25 (link)].

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Colunga A.L., Colebank M.J, & Olufsen M.S. (2023). Parameter inference in a computational model of haemodynamics in pulmonary hypertension. Journal of the Royal Society Interface, 20(200), 20220735.

Publication 2023

Arterial Blood pressure measurements Cardiac output Cardiovascular system Diagnosis Diastolic systemic arterial pressure Heart Pressure Pulmonary Pulmonary arterial Pulse pressure Ra 25 Stroke Systolic Ventricular function

Corresponding Organization : North Carolina State University

Other organizations : Edwards Lifesciences (United States), University of California, Irvine

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Stroke work, defined as the integral of the pressure-volume loop for each heart chamber
Resistance ratio, defined as the pulmonary and systemic resistance ratio (Rp/Rs)
Compliance ratio, defined as the ratio of pulmonary and systemic arterial compliance (Cpa/Csa)
Pulsatility index (PI), defined as the ratio of pulmonary arterial pulse pressure to average right atrial pressure

control variables

Not explicitly mentioned

Annotations

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