Comprehensive Cancer Patient Data Collection

Medical data collected for each patient in order to correlate biological data (including PDTO response to treatment) with clinical response are indicated in Table 2.Table 2

Medical data collected for each patient

Clinical parameters	Age, sex, weight, height, ECOG performance status, Exposure to tobacco and alcohol, Cancer location and TNM-8 classification
Histological diagnosis	Type, squamous differentiation, keratinization type, p16 status
Biologic parameters	Serum neutrophils, albumin and leukocytes levels
Pathological pronostic factors	Surgical margin, lymph node metastasis with or without capsular rupture, vascular or lymphatic embolization, perineural invasion
Oncologic treatments	Radiotherapy (volume, dose, fraction) Chemotherapy (molecules, administration regimen)
Response to treatment	Disease-free survival, Progression-free survival, Overall survival.

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Perréard M., Florent R., Divoux J., Grellard J.M., Lequesne J., Briand M., Clarisse B., Rousseau N., Lebreton E., Dubois B., Harter V., Lasne-Cardon A., Drouet J., Johnson A., Le Page A.L., Bazille C., Jeanne C., Figeac M., Goardon N., Vaur D., Micault E., Humbert M., Thariat J., Babin E., Poulain L., Weiswald L.B, & Bastit V. (2023). ORGAVADS: establishment of tumor organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies. BMC Cancer, 23, 223.

Publication 2023

Administration regimen Albumin Alcohol Biological Cancer Capsular Chemotherapy Ecog Embolization Leukocytes Lymph node metastasis Neutrophils Patient Tobacco Vascular

Corresponding Organization :

Other organizations : Cancers et Préventions, Centre François Baclesse, Université de Lille, Laboratoire de Physique Corpusculaire de Caen, École Nationale Supérieure d'Ingénieurs de Caen

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Variable analysis

independent variables

Radiotherapy (volume, dose, fraction)
Chemotherapy (molecules, administration regimen)

dependent variables

Disease-free survival
Progression-free survival
Overall survival

control variables

Weight
Height
ECOG performance status
Exposure to tobacco and alcohol
Cancer location and TNM-8 classification
Histological diagnosis type, squamous differentiation, keratinization type, p16 status
Serum neutrophils, albumin and leukocytes levels
Surgical margin
Lymph node metastasis with or without capsular rupture
Vascular or lymphatic embolization
Perineural invasion

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