Synthesis of Phenylphosphine Oxide

tert-Butyl(phenyl)phosphine chloride (1.003 g, 10.00 mmol) and 20 mL dichloromethane were added to a dry round bottom flask, which was filled with nitrogen. And then pure water (0.1802 g, 10.00 mmol) was slowly added dropwise under ice bath. When all the pure water had been added, the resulting solution was allowed to warm to room temperature and stirred for 5 h. After the hydrolysis reaction was completed, the mixture was directly rotary evaporated to obtain a white solid compound 2a (0.8864 g, 97% yield). ¹H NMR (400 MHz, CDCl₃): δ = 7.70–7.48 (m, 5H), 1.16 (dd, J = 17.0, 1.3, 9H). ¹³C NMR (101 MHz, CDCl₃): δ = 132.88 (d, J = 2.8), 131.09 (d, J = 10.3), 128.70 (d, J = 11.9), 31.97 (d, J = 68.8), 23.42 (d, J = 2.2). ³¹P NMR (162 MHz, CDCl₃): δ 49.24. MS (ESI⁺): Calcd for C₁₀H₁₆OP [M + H]⁺ requires 183.1, found 183.1. (NMR spectra were shown in Additional file 1: Figure S20–S22, and MS spectrum was shown in Additional file 1: Figure S54.)