Streptozotocin-Induced Type 1 Diabetes in Rats

Rats received one-time intraperitoneal injection of streptozotocin (STZ, 50 mg/kg) (STZ, Sigma Chemical Co., St. Louis, MO, USA) to develop type 1 diabetes^{14 (link)}. STZ was dissolved in 0.1 M citrate buffer (pH 4.5). One Touch Ultra Glucose meter was used to measured blood glucose 7 days following STZ injection (Roche, USA). Diabetic rats were defined as rats with glucose levels equal to or more than 20 mmol/L. Rats that did not meet the criteria were excluded.

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Liu X., Chen H., Yan Z., Du L., Huang D., Gao W.D, & Hu Z. (2021). Remote liver ischemic preconditioning attenuates myocardial ischemia/reperfusion injury in streptozotocin-induced diabetic rats. Scientific Reports, 11, 1903.

Publication 2021

STZ One Touch Ultra Glucose meter

Blood glucose Buffer Citrate Glucose Intraperitoneal injection Rats Touch

Corresponding Organization :

Other organizations : Sichuan University, West China Hospital of Sichuan University, Johns Hopkins Medicine, Johns Hopkins University

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Variable analysis

independent variables

Intraperitoneal injection of streptozotocin (STZ, 50 mg/kg)

dependent variables

Blood glucose levels

control variables

0.1 M citrate buffer (pH 4.5) used to dissolve STZ
One Touch Ultra Glucose meter used to measure blood glucose

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

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