Timing of DOAC Initiation and Outcomes

Patients were categorized based on long-term anticoagulant (DOAC, warfarin, or enoxaparin). To examine the timing of DOAC initiation with outcomes, patients receiving a DOAC were categorized as having initiation <48, 48-72, and >72 h from thrombolysis. The primary outcome was hospital LOS (days). Secondary outcomes included ICU LOS, hospital LOS after oral anticoagulation initiation, in-hospital bleeding events, 30-day readmission, 90-day major and minor bleeding,^{12 (link)} VTE/stroke, and mortality. Clinical and demographic measures included age, sex, semi-quantitative RV size on echocardiogram, simplified pulmonary embolism severity index, and continuous measures of serum creatinine, troponin, brain natriuretic protein (BNP), weight, heart rate, systolic blood pressure, and respiratory rate.

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Wolfe A., Phillips A., Tierney D.M., Melamed R., Qadri G., Lillyblad M., Smith C., St. Hill C., Stenzel A.E., Beddow D., Kirven J., Kethireddy R, & Patel L. (2023). Retrospective Analysis of Direct-Acting Oral Anticoagulants (DOACs) Initiation Timing and Outcomes After Thrombolysis in High- and Intermediate-Risk Pulmonary Embolism. Clinical and Applied Thrombosis/Hemostasis, 29, 10760296231156414.

Publication 2023

30 day readmission Anticoagulant Brain Creatinine Echocardiogram Enoxaparin Heart rate Patients Protein Pulmonary embolism Respiratory rate Serum Stroke Systolic blood pressure Thrombolysis Troponin Warfarin

Corresponding Organization : Allina Health

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Variable analysis

independent variables

Timing of DOAC initiation with outcomes (<48, 48-72, and >72 h from thrombolysis)

dependent variables

Hospital length of stay (LOS) (days)
ICU LOS
Hospital LOS after oral anticoagulation initiation
In-hospital bleeding events
30-day readmission
90-day major and minor bleeding
90-day VTE/stroke
Mortality

control variables

Semi-quantitative RV size on echocardiogram
Simplified pulmonary embolism severity index
Serum creatinine
Troponin
Brain natriuretic protein (BNP)
Weight
Heart rate
Systolic blood pressure
Respiratory rate

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