Genetic and Epigenetic Factors in PAAD

Genetic alterations, including gene mutations and copy number alterations, are the potential factors impacting expression. We evaluated the genetic alterations of CDCAs with Oncoprinter from cBioportal and the impacts of CDCAs on PAAD patient survival23 (link), 24 (link). DNA methylation is another risk factor that affects the expression of CDCAs. The influence of DNA methylation on CDCA expression was assessed by DNMIVE25 (link), and the impact of a single-methylation CpG site on the OS of PAAD patients was analyzed by MethSurv26 (link).

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Xing C., Wang Z., Zhu Y., Zhang C., Liu M., Hu X., Chen W, & Du Y. (2021). Integrate analysis of the promote function of Cell division cycle-associated protein family to pancreatic adenocarcinoma. International Journal of Medical Sciences, 18(3), 672-684.

Publication 2021

Cdca Copy number alterations Dna methylation Genetic alterations Methylation Patients

Corresponding Organization :

Other organizations : Anhui Medical University, First Affiliated Hospital of Anhui Medical University

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Variable analysis

independent variables

Genetic alterations, including gene mutations and copy number alterations
DNA methylation

dependent variables

Expression of CDCAs
Survival of PAAD patients

control variables

Not explicitly mentioned

controls

Positive controls: Not specified
Negative controls: Not specified

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