Continuous variables are presented as the median and interquartile range and categorical variables as the number and percentage. The %FVC was not known in healthy controls but was assumed to be 100%. Hence, serum IL-11/%FVC values were calculated using the serum levels of IL-11/100 in healthy controls. The values for continuous variables in the two groups were compared using the Wilcoxon rank-sum test. The correlation between the two parameters was examined using Spearman’s rank correlation analysis.
The significance of each clinical parameter and serum levels of IL-11 and PDGF as predictors of survival and AE occurrence were determined by univariate and multivariate Cox proportional hazards regression analyses with a stepwise selection method. The serum cytokine/% FVC value was used to compare local production of each cytokine according to lung volume.
All statistical analyses were performed using SPSS for Macintosh (version 26; IBM Corp., Armonk, NY, USA). Statistical significance was set at P<0.05.
The significance of each clinical parameter and serum levels of IL-11 and PDGF as predictors of survival and AE occurrence were determined by univariate and multivariate Cox proportional hazards regression analyses with a stepwise selection method. The serum cytokine/% FVC value was used to compare local production of each cytokine according to lung volume.
All statistical analyses were performed using SPSS for Macintosh (version 26; IBM Corp., Armonk, NY, USA). Statistical significance was set at P<0.05.
