PSCAE gene, UPII gene, and E1A gene express in the recombinant adenovirus were identified by PCR. Firstly, harvested viruses were digested by proteinase K (Takara Biotechnology Co., Dalian, China), and then extracted virus DNA. PCR were performed according to PCR Reaction Kit (Takara) instruction. Gene expression bands were observed by agarose gel electrophoresis. The primer sequences were listed in Table 1 [9 (link), 18 (link)].
The primers used for polymerase chain reaction (PCR)
Cao W., Tian J., Li C., Gao Y., Liu X., Lu J., Wang Y., Wang Z., Svatek R.S, & Rodriguez R. (2017). A novel bladder cancer - specific oncolytic adenovirus by CD46 and its effect combined with cisplatin against cancer cells of CAR negative expression. Virology Journal, 14, 149.
Proteinase K (Takara Biotechnology Co., Dalian, China) used to digest harvested viruses
PCR Reaction Kit (Takara) used to perform PCR
controls
Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned
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