Univariable or multivariable Cox proportional hazards models were used to examine the association between mutations and survival. BCSS was used as the endpoint. Patients with deaths due to other or unknown causes were censored at the date of death, and all other patients were censored at the date of last contact. For the multivariable models, we included as variables: grade size (greater or less than 50 mm), lymph node status (positive or negative) and age (greater or less than 55). This coding scheme was chosen taking into consideration the minimum level of data available across the cohorts in the study. The same scheme was used when performing logistic regression for identifying associations between clinical parameters and mutation presence. To identify associations between events, we used Fisher's exact test for 2 × 2 contingency tables.
Pereira B., Chin S.F., Rueda O.M., Vollan H.K., Provenzano E., Bardwell H.A., Pugh M., Jones L., Russell R., Sammut S.J., Tsui D.W., Liu B., Dawson S.J., Abraham J., Northen H., Peden J.F., Mukherjee A., Turashvili G., Green A.R., McKinney S., Oloumi A., Shah S., Rosenfeld N., Murphy L., Bentley D.R., Ellis I.O., Purushotham A., Pinder S.E., Børresen-Dale A.L., Earl H.M., Pharoah P.D., Ross M.T., Aparicio S, & Caldas C. (2016). The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes. Nature Communications, 7, 11479.
Other organizations :
Cancer Research UK, University of Cambridge, Oslo University Hospital, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Illumina (United Kingdom), Nottingham University Hospitals NHS Trust, University of Nottingham, Kingston General Hospital, Queen's University, Research Institute in Oncology and Hematology, Guy's and St Thomas' NHS Foundation Trust, King's College London, University of Oslo
Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.
As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to
get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
