Computed Tomography Imaging of Sheep Brains

Computed tomography (CT) scans were performed on treated sheep every 2 to 4 months (Russell et al., 2018 (link)). Helical slices were obtained at 1 mm intervals, 120 kV, 100 mA, 2 s rotation time on a GE HD750 CT scanner (GE Healthcare, Hyugo, Japan). Three-dimensional (3D) modelling and intracranial volumetrics were performed using the 3D slicer 4.3.1 freeware (http://www.slicer.org; RRID:SCR_005619) (Federov et al., 2012 (link); Russell et al., 2018 (link)).

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Mitchell N.L., Murray S.J., Wellby M.P., Barrell G.K., Russell K.N., Deane A.R., Wynyard J.R., Palmer M.J., Pulickan A., Prendergast P.M., Casy W., Gray S.J, & Palmer D.N. (2023). Long-term safety and dose escalation of intracerebroventricular CLN5 gene therapy in sheep supports clinical translation for CLN5 Batten disease. Frontiers in Genetics, 14, 1212228.

Publication 2023

GE HD750 CT scanner

Computed tomography Computed tomography scanner Helical Scans Sheep

Corresponding Organization : University of Otago

Other organizations : The University of Texas Southwestern Medical Center

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Variable analysis

independent variables

Time between computed tomography (CT) scans (2 to 4 months)

dependent variables

Intracranial volume

control variables

CT scanner model (GE HD750)
CT scan settings (1 mm slice intervals, 120 kV, 100 mA, 2 s rotation time)
Image analysis software (3D Slicer 4.3.1)

controls

Positive control: Not mentioned
Negative control: Not mentioned

Annotations

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