The study was approved by the London Riverside national research ethics committee (Ref 10/H0706/35), and all participants gave informed written consent in accordance with the Declaration of Helsinki. Whereas the healthy participants only attended a single session, all patients attended two appointments, one at baseline and a follow-up appointment (∼6 months after surgery/baseline appointment). In patients with CTS, the hand that was operated (surgery group) or the hand that was more affected (no-surgery group) was tested, whereas the non-dominant hand was tested in healthy controls. All clinical measurements were collected by the same experienced examiner to ensure consistency.
Prospective Longitudinal Study of CTS
The study was approved by the London Riverside national research ethics committee (Ref 10/H0706/35), and all participants gave informed written consent in accordance with the Declaration of Helsinki. Whereas the healthy participants only attended a single session, all patients attended two appointments, one at baseline and a follow-up appointment (∼6 months after surgery/baseline appointment). In patients with CTS, the hand that was operated (surgery group) or the hand that was more affected (no-surgery group) was tested, whereas the non-dominant hand was tested in healthy controls. All clinical measurements were collected by the same experienced examiner to ensure consistency.
Corresponding Organization : University of Oxford
Other organizations : Danish Pain Research Center, University of Glasgow, Nuffield Orthopaedic Centre
Protocol cited in 8 other protocols
Variable analysis
- Surgical treatment (surgery vs. no surgery)
- Clinically and electrodiagnostically confirmed CTS
- Abnormalities other than CTS (revealed by electrodiagnostic testing)
- Medical condition affecting the upper limb and neck (e.g. hand osteoarthritis, cervical radiculopathy)
- History of significant trauma to the upper limb or neck
- CTS related to pregnancy or diabetes
- Gender
- Lack of any systemic medical condition
- Lack of history of hand, arm or neck symptoms
- Positive control: Patients with clinically and electrodiagnostically confirmed CTS
- Negative control: Healthy volunteers without any systemic medical condition or history of hand, arm or neck symptoms
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