Mice were i.p. injected with a therapeutic dose (100 mg/kg) of gentamicin at 3 h after MRSA infection and then followed by 50 mg/kg/d (Espersen et al., 1994 (link)). In some experiments, mice were treated s.c. with 50 mg/kg/d linezolid (Pfizer Inc.) or 150 mg/kg/d vancomycin beginning 2 h after MRSA infection (Reyes et al., 2011 (link); Niska et al., 2013 (link); Schuch et al., 2014 (link)). Control mice received PBS. All antibiotic treatment and sham injections continued through day 10 after MRSA infection.
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Antibiotic Treatment for MRSA Infection in Mice
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Corresponding Organization : Albany Medical Center Hospital
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Variable analysis
independent variables
- Antibiotic treatment with gentamicin (100 mg/kg followed by 50 mg/kg/d)
- Antibiotic treatment with linezolid (50 mg/kg/d)
- Antibiotic treatment with vancomycin (150 mg/kg/d)
- Outcome (not explicitly mentioned)
- Time of antibiotic treatment (starting at 3 h or 2 h after MRSA infection)
- Duration of antibiotic treatment (through day 10 after MRSA infection)
- Control mice received PBS
- Positive control: Not specified
- Negative control: PBS-treated mice
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