Hemodynamic Analysis of Pulmonary Hypertension

This study uses clinically de-identified RHC data from nine patients with confirmed PH: five with PAH and four with CTEPH. Three CTEPH and three PAH datasets are from Duke University, and one CTEPH and two PAH datasets are from the Scottish Pulmonary Vascular Unit. Static data include height (cm), weight (kg), sex (male (m) or female (f)), age (years), heart rate (bpm), and systolic, diastolic and mean systemic blood pressure (mmHg) measured by a blood pressure cuff. The patients underwent RHC, where a catheter is advanced from the right atrium, to the right ventricle, and to the main pulmonary artery. Dynamic pressure waveforms are recorded in each compartment. The pulmonary arterial wedge pressure (PAWP, mmHg), an estimate of left atrial pressure, is also recorded. CO (l min⁻¹) is measured during the RHC by thermodilution. All pressure readings are obtained over 7–8 heartbeats. Demographics are provided in table 1.
Table 1.

Patient demographics; group 1: pulmonary arterial hypertension (PAH); group 4: chronic thromboembolic pulmonary hypertension (CTEPH).

patient	PH	age (years)	sex	height (cm)	weight (kg)	CO (l min−1)
1	1	64	male	164.0	72.6	4.0
2	4	58	male	161.0	70.0	4.3
3	1	27	female	151.0	81.1	2.6
4	4	71	female	167.6	93.3	6.1
5	4	51	male	179.1	117.2	3.6
6	1	—	male	178.0	108.0	6.4
7	1	—	male	179.0	74.0	6.3
8	1	—	female	183.0	82.0	5.6
9	4	—	female	154.9	67.4	4.0

CO, cardiac output; PH, pulmonary hypertension. For patients 6–9, age was not included in the medical records.