Nicotine Replacement Therapy Comparison

Two NRT products were tested, Nicorette Peppermint 2 mg lozenge, and Nicotinell Licorice 2 mg gum. The products weigh 0.6 g and 1.2 g per unit of use, respectively. The lozenge contains nicotine in the form of resinate, fillers (mannitol, xanthan gum, gum arabic, magnesium stearate, hypromellose, titanium dioxide, microcrystalline cellulose, potassium silicate, polysorbate 80), pH adjuster (sodium carbonate), sweetener (sucralose, acesulfame K) and flavorings. The gum contains nicotine polacrilex, chewing gum base, sweetener (acesulfame K, saccharin, sodium saccharin, sorbitol, xylitol, mannitol), pH adjusters (calcium carbonate, sodium carbonate, sodium bicarbonate), flavoring, glycerol, gelatine, titanium dioxide, canauba wax and talcum powder.

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Back S., Masser A.E., Rutqvist L.E, & Lindholm J. (2023). Harmful and potentially harmful constituents (HPHCs) in two novel nicotine pouch products in comparison with regular smokeless tobacco products and pharmaceutical nicotine replacement therapy products (NRTs). BMC Chemistry, 17(1), 9.

Publication 2023

Acesulfame k Calcium carbonate Chewing gum Gelatine Glycerol Gum arabic Hypromellose Licorice Magnesium stearate Mannitol Microcrystalline cellulose Nicorette Nicotine Nicotine polacrilex Peppermint Polysorbate 80 Potassium Saccharin Silicate Sodium bicarbonate Sodium carbonate Sodium saccharin Sorbitol Sucralose Sweetener Talcum powder Titanium dioxide Xanthan gum Xylitol

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Variable analysis

independent variables

Nicorette Peppermint 2 mg lozenge
Nicotinell Licorice 2 mg gum

dependent variables

Not explicitly mentioned

control variables

Weight per unit of use (0.6 g for lozenge, 1.2 g for gum)
Composition of lozenge (nicotine resinate, fillers, pH adjuster, sweeteners, flavorings)
Composition of gum (nicotine polacrilex, chewing gum base, sweeteners, pH adjusters, flavorings, other ingredients)

controls

No positive or negative controls were explicitly mentioned

Annotations

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