Teicoplanin Pharmacokinetics in ICU Patients

This single-center, prospective, observational study was performed in ICU of Guangdong Provincial People’s Hospital from July 2018 to January 2020. The inclusion criteria were applied: age ≥18 years, receiving teicoplanin (Targocid, Sanofi Co, Guangdong, China) intravenously, diagnosed or suspected clinically with Gram-positive infections. Exclusion criteria were patients who lacked any of the demographic and laboratory data described below. Demographic and clinical characteristics were collected including age, sex, body weight, serum creatinine concentrations (Scr), serum albumin concentrations (ALB). Creatinine clearance (Ccr) was calculated by the Cockcroft-Gault formula. The estimated glomerular filtration rate (eGFR) was calculated by CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation.20 (link) In addition, other clinical information including teicoplanin doses and dosing intervals, each time point of sample collection, the continuous renal replacement therapy (CRRT) status, baseline acute physiology and chronic health evaluation (APACHE) II scores were also recorded.

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Wang Y., Yao F., Chen S., Ouyang X., Lan J., Wu Z., Wang Y., Chen J., Wang X, & Chen C. (2023). Optimal Teicoplanin Dosage Regimens in Critically Ill Patients: Population Pharmacokinetics and Dosing Simulations Based on Renal Function and Infection Type. Drug Design, Development and Therapy, 17, 2259-2271.

Publication 2023

Targocid

Body weight Chronic kidney disease Continuous renal replacement therapy Creatinine Glomerular filtration rate Infections Patients Physiology Sample collection Serum Serum albumin Targocid Teicoplanin

Corresponding Organization :

Other organizations : Southern University of Science and Technology, Jinan University, South China University of Technology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Third Affiliated Hospital of Southern Medical University

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Variable analysis

independent variables

Teicoplanin (Targocid, Sanofi Co, Guangdong, China) intravenously

dependent variables

Demographic and clinical characteristics including age, sex, body weight, serum creatinine concentrations (Scr), serum albumin concentrations (ALB)
Creatinine clearance (Ccr) calculated by the Cockcroft-Gault formula
Estimated glomerular filtration rate (eGFR) calculated by CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation
Teicoplanin doses and dosing intervals
Continuous renal replacement therapy (CRRT) status
Baseline acute physiology and chronic health evaluation (APACHE) II scores

control variables

Age ≥18 years
Diagnosed or suspected clinically with Gram-positive infections

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