The sample size was determined a priori based on effect sizes of previous studies6 (link),10 (link),11 (link),106 (link),107 (link) or by post hoc analyses to ensure >80% power was achieved to reduce type II error (for example, heart histology, developmental milestone achievement and cognition in adults). All statistical analyses were conducted in GraphPad Prism v8.0.1 or R v4.0.1 (refs. 108 ,109 ) and are listed with sample sizes in the corresponding figure legends. Preprocessing, statistical analysis and initial plot generation for all datasets were carried out using R v4.0.1. Method schematics were generated using Biorender.com. All figures were finalized in Adobe Illustrator v24.1.
Waugh K.A., Minter R., Baxter J., Chi C., Galbraith M.D., Tuttle K.D., Eduthan N.P., Kinning K.T., Andrysik Z., Araya P., Dougherty H., Dunn L.N., Ludwig M., Schade K.A., Tracy D., Smith K.P., Granrath R.E., Busquet N., Khanal S., Anderson R.D., Cox L.L., Estrada B.E., Rachubinski A.L., Lyford H.R., Britton E.C., Fantauzzo K.A., Orlicky D.J., Matsuda J.L., Song K., Cox T.C., Sullivan K.D, & Espinosa J.M. (2023). Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model. Nature Genetics, 55(6), 1034-1047.
Other organizations :
University of Colorado Anschutz Medical Campus, University of Missouri–Kansas City, National Jewish Health, University of Colorado Denver
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